Tuesday, March 15, 2011

El Dorado

After arriving somewhat late on account of not finding the room right in front of my eyes, I came to a room filled with other prospectives presided by an associate dean.  The mood was a professional, uncomfortable silence.  We were briefed about the program, the location, the highlights, etc., all the bells and whistles that they had to offer.  With not a minute to spare, I was whisked off to my first meeting by an assistant.

Bartholemeu Dias:  Poofed hair, baggy & slouchy shirt, uni-brow, computer lost in the general clutter of papers and books; general appearance of a person absorbed more into work than in appearances.  She looked to the ceiling when she spoke, as if imagining her thoughts forming above her.  The only time she ever made eye contact with me was when I was answering her questions.  After hearing my spiel about the work that I currently do, she questioned whether I agreed with the ethics of mass genetics testing.  Is it ethical for a company, like mine, to give out genetics results to patients for complex conditions with medical implications?  The ultimate goal for a industry laboratory is revenue.  Yes, patients come first, but money must also follow the patient, or otherwise there is no company.  That said, even though money is the driving force, there are ethical guidelines enforced by the government that all laboratories must follow.  That is the reason for the validation stages that these assays must go through before being tested with actual patient DNA.  That is the reason why there is a medical director presiding over the research and development projects before such tests are advertised to clients.  That is the reason why there is a Quality Control and Assurance department.  Every laboratory worth their salt has no choice but to comply with the prescribed guidelines.  Of course my answer while on the hot seat wasn't so articulate (not to say this is articulate), but I made my point.  After hearing my answer, Bartholomeu half chuckled and said: "Interesting.  I guess I know where you stand."  Good or bad I have no idea.


Francisco Pizarro:  His office was way across campus, in it's own little building, with his own secretary.  When the secretary opened the door to let me in, I felt as though I was reliving Harry Potter's moment when he first stepped into Dumbledore's office.  This place had a quiet grandeur to it with light pouring in from the many windows.  When I commented the nice sofa set he has in his office, Pizarro admitted that his office is "embarrassingly large."  Similar to the way that Dumbledore's reputation precedes him, I felt myself trembling a bit as I sat down in front of Pizarro because I had read and heard so much about him.  Yet, he couldn't have felt more comfortable and relaxed as he propped his feet on the coffee table revealing the ragged sneakers he wore that day.  I, on the other hand, was in a suit sitting at the edge of my seat talking so intensely that I forgot to breathe.  Surely he would grill me on both sides just to see what I was made of... surely so, I thought.  Instead, he was just a most soft-spoken, mild-mannered, world-weary person to whom I talked of my background and experiences and motivations.  We also talked of drunken fruit-flies and college freshmen, but that's another topic for another day...


Hernando Cortez:  Again, a trek and a half across campus to this far-away office.  Prior to my meetings, I prefer to do some research on the person who I'll be talking to.  I do this in the hopes of increasing my chances of saying something intelligent and also reducing my chances of saying something utterly stupid during my meeting.  Cortez does not have any relevant research background or information that I could find on Google, and not being able to find this out prior to meeting Cortez put me at extreme unease.  Stepping into his office, I gathered why information on him was so hard to come by... he is newly appointed to El-Dorado and is just beginning to settle into his position.  Cortez spoke with a thick accent; I'm sure I had my eyebrows scrunched during most of the meeting because I had to concentrate on understanding him.  Background talks aside, we talked of new technologies and advancement in drugs.  He educated me off on a few interesting things such as MDA-7/IL-24, and exedin-3 in diabetes.  I didn't know it at the time, but these things have been published for quite a few years now, and I really should have known more about it while talking to him.  Nearing the end of the meeting, I asked him why he chose the field of cancer genetics.  Cortez smiled as if he had been anticipating my question for a while.  He then pointed to a faded wallet-sized photo at the far corner of his desk.... his father.  From what I can gather, Cortez's father was diagnosed with pancreatic cancer.  I couldn't hear well enough to learn if his father is still living or deceased, and I did not want to prod and make him uncomfortable.  His father is his inspiration.  Even if he could elucidate just a tiny piece of information to add to the knowledge of cancer research, he would make his father proud.

Vasco Nunez de Balboa:  It's funny that man I've heard of and even crossed paths a few times before could make me so nervous.  Maybe it's because we've never had a formal introduction, or that I've found him to be too intimidating that when it came time for me to formally meet him I almost didn't want to do it.  His office moved from where I last knew it, to the dark and gloomy third floor where no one else goes.  Also, his hair changed from when I last saw him (or maybe I just didn't pay that much attention).  Actually his hair very much amused me; it looked like there was a stiff, gray brush in the shape of a fan on his head.  Like Cortez, his accent is very heavy, though not the same accent.  The conversation began somewhat patchy but progressed as I asked him some questions about why he does what he does.  I get the feeling that he is a person that bores easily and is always on the lookout for that new challenge that no one else could figure out.  Once he has figured out something the thrill goes away and he's on to something else.  I also get the distinct impression that his teaching style is very laissez-faire, meaning he is very independent and would work well with someone else who is equally independent.  His thoughts on types of researchers: horizontal and vertical.  Horizontal types learn a new technique/method/assay/technology really well, and then apply the same technique/method/assay/technology to new problems.  Vertical types learn about a problem/issue and figure out different technique/method/assay/technology to solve different aspects of that problem/issue.  Which type is he?  Vertical.

My day on the hot seats was exhausting not only mentally, but physically too from all that trekking around.  At the end of the day I felt like I had been holding my breath all day long.  Yet, I felt good.  I had an unexplainable good feeling about the day.  Good, bad, ugly, I had no idea, but I left all the interviews with a smile on my face.

Next visit: Shangri-La

Wednesday, February 16, 2011

Nearly Wordless Wednesday


So beautiful, but so vain.  Yet so precious. 

Tuesday, February 15, 2011

Some thoughts on V-Day

My highschool use to have this cruel tradition that began at the start of every February.  Either the PTA, or the Interact Club, or some other school club would buy a boat-load of carnations and then re-sell them at $1 each.  The students buy tickets from these clubs for their friends, admirers, "significant" others... and the flowers get delivered to that person on February 14.  The school clubs raise some money for their treasury, and the students get to feel special on Valentine's day.  Win-win situation, right?  Not exactly.

The whole situation inevitably turned into a popularity contest.  The girl (or guy) who was most weighed-down with carnations that day was the envy of everybody else.  Naturally every one wanted to be that person, though no one was vain enough to admit it.  On the other hand, if you were some poor lad/gal who walked the halls that day with not a single carnation in sight... then you might as well have had a sign on your back that said "Loser."

Of course no one wanted to be that lonely person, myself included.  With no boyfriend to coerce into buying me flowers, I took matters into my own hands.  To ensure that at least one carnation would arrive, that on V-day I would be associated with some hint of a pink floral petal, and mostly, that I would not be grouped with the "loners" club, I made alliances with my friends.  You see, they were also thinking what I was thinking, and so it made perfect sense for us to align our forces.  I would buy them a carnation, and in return, I would get a carnation.  Why go through the whole hoopla?  Why not just buy myself the darn flower and call it a day?  Well, because it's just not special if you buy yourself a flower, is it?  Then, not only are you "lonely," but you'd also be "desperate," and that's a whole other level of sad.

Admittedly, I was rusty at the beginning of the whole process.  I'd have trouble initiating the process, even though I knew my friends were all thinking the same things.  But I got better every year, and by senior year, I was walking down the halls with a bouquet of carnations!  I exaggerate, but I had enough flowers that it looked obnoxiously cumbersome.  Mind you, I was never "that" girl with the flowers that everyone else envied; I was never that popular, and of my five flowers were essentially swapped deals!  But... to some unsuspecting, naive freshman, I could have definitely passed as somewhat well-liked among my social group.  If nothing else, then I would have not been associated with the "loners." 

It's quite funny looking back on the whole carnation situation.  That a single flower could have so much social significance is outrageously comical to an adult, but to a high-school kid, that single flower meant all the difference.  The whole situation could have been a lot less stressful had I had a romantic somebody, someone who was with me in a way that obligated them to buy me the carnations without any swaps involved.  Alas, that was never the case with me.

Even after high-school, and throughout college, I never had a significant other on V-Day.  This was never a big issue I had, as most of my friends were also like me: single.  We hung out on V-Day just as with any other day, and it was never blatant that we were without roses and chocolates and candlelit dinners.  Although I never lamented being single on V-Day, the thoughts did cross my mind once or twice that it would be nice to have someone with whom to celebrate love.  Flowers would be lovely, I thought. 

 Indeed, flowers are lovely.


You would think that after being with someone for two Valentines now, that I require, even demand, the requisite flowers.  It is surprising then, even to myself, that I've come to view V-Day a lot differently now then I did back in highschool.  Somewhere along the years, I came to the conclusion that V-Day is more a Hallmark holiday.  I reasoned that real lovers do not need a day dedicated to celebrate love; truly in love people celebrate love every day.  Furthermore, I, being the snob that I am, do not want to celebrate my love along with the rest of the world.  After all, how could romance be truly romantic if every other couple were doing the same thing?  I do not bash the holiday, as it is always good to have more love going around, even if the greeting card companies are behind it all.  Love is so good indeed that it shouldn't be confined to one day out of the year. 

 It is quite simple.  Above everything, above the carnations and roses... above all else, all anyone really ever yearns for is simply to be loved.  And loved is what I am.

Thursday, February 10, 2011

The hardest challenge....

One of the most difficult challenges is getting up after a nasty fall, figuratively speaking of course.  How do you muster the strength to get up, dust yourself off, and stand tall again after being knocked down so brutally?  Up until this change, I believed I was invincible; I could walk on water if I really tried....

As hard as it may be, we always get back up.  We must.  There is no alternative.  We must get back up.  It takes time, to slowly erode away the memory of the crushing pain.  It takes introspection, lots of introspection, to figure out why it happened, and what can be done about it.  It takes outside support, because we all need someone to lean on sometimes, as cheesy as that may sound.  Looking back, I am incredibly grateful for all the unwavering support from the people in my life. 

 So, to stand up again is a monumental effort in its own right.  Yet, to climb back up on the proverbial horse is like facing Everest.  I exaggerate, but it's not too far from the truth in my humblest opinion.  To put yourself out there again, giving everything you have, can make a person feel so vulnerable, so bare and exposed.

 Melodramatics aside, the bottom line is simple: Falls are inevitable; giving it another try is not optional.

*** "You're really the only shadow standing in your own sunshine." - Fabio from Top Chef. ***

Monday, January 17, 2011

Halcion: thou art mighty

Wisdom teeth: any of the third molars, usually appearing in the late teens, early 20s;

Impacted wisdom teeth:  those growing in horizontally, or in any other odd positions, that would impact the other teeth and would need to be removed

Anxiety:  adaptive response to an impending danger that is integral to an organism's ability to cope with or avoid a stress (Pham, X. 2009 ) :D

Halcion:  generic name = triazolam; a benzodiazapine derivative with sedative and hypnotic properties.  It was used to treat insomnia but is not popular now as it is known to have a high dependency rate and has some pretty terrible side-effects.  It is still used by dentists, however, when they need their patients to be completely and utterly knocked out for procedures, such as, oh I don't know... wisdom teeth extractions, maybe?

1/7/11: My original appointment for the four extractions.  I chickened out and had to reschedule.


1/13/11: I picked up some prescriptions from the pharmacy that the dentist's office called in for me. Instructions: take one Halcion before going to bed.  Done.  While on the phone after taking the pill, I mentioned that I didn't feel anything, no drowsiness, no sedation.  I said that I was worried the medication wasn't working, and that I would be awake for the procedure the following day.  I don't remember the rest of the conversation, and I was only told later that I fell asleep in the middle of talking on the phone.

1/14/11: Instructions: take 2 Halcion pills one hour before appointment.  I took the 2 little blue pills at 9am, and laid down to watch some TV before being picked up for the dentist.  I don't remember what I watched.  I vaguely remember answering the phone at 9:30am.  As my mom recalls, she heard a huge thud from upstairs at around that time, so I'm guessing that I must have fallen out of my bed.  I remember nothing else.  Per my sister's recollection, she saw me stagger and stumble down the stairs like a drunkard, swaying heavily as I walked, and stopped at the front door to look outside.  Supposedly, I was laughing all the way down as I muttered something.  I then turned to her, and fell backwards on the ground, and laid there laughing.  She helped me up and walked me outside, where my bf took over and helped me into the car.  Apparently I screamed at him for not closing the car door fast enough, because I was cold.  Again, I remember nothing!

At the dentist's office, I stumbled in and fell into the chair.  He took a look at me, and proceeded to crush up my 2 remaining Halcion pills, and told me to drink up.  It was all black after that.  I have some blurry memories of a gas mask being put on me, and that at some point in time, I had to use the bathroom.  I recall the dentist yelling out to my bf my teeth status: "2 out, 2 more to go!"  I remember my nose itching and scratching it.  Two hours later, I remember at the end when I was coming out of it, that through my gauze-filled mouth, I asked if I can keep my teeth. 

I don't remember the drive home, or how I got back into bed.  I woke up, or was woken up, periodically to changed my bloody gauze pads.  And I slept.  I slept like the dead.  At one point I remember the pain being excruciating on the right side of my jaw (he had some trouble with that tooth) and was crying.  Good thing the doc gave me some hydrocodone.  I managed to be awake for a bit to put down some applesauce, but it came back up, along with some chunks of brown blood that I'm guessing I swallowed during the procedure.

I'm most thankful for the Halcion for getting me through the procedure.  One of the things I was most anxious about was not the pain during the procedure; I was sure they would make it so I wouldn't feel anything.  What I was worried about was whether or not I would be awake, and so would be able to hear the drills, the cracks, the cutting & sawing.  And also, if I was awake, I would smell the burning of the drills and the flesh, and that is more freaky to me than anything else.  So, to have no recollection of the two hours I spent in the dentist chair is a blessing.  As for the other stuff, I wish there was a way I could watch myself tumble about that Friday morning. 

One of the reasons Halcion is no longer being used to treat insomnia is because of its effects the following nights.  Halcion has a tendency to cause rebound insomnia, in which case more drugs are needed to treat the problem.  Although I was only on the drug for a short time, I took into my system 5 pills at 0.25mg apiece in the span of about 12 hours.  I slept gloriously through the procedure, and for the rest of the day, through most of the pain.  However, that night, I could not sleep a wink.  My eyes refused to shut, and my brain would not slow down.  I ended up staying awake the entire night, watching YouTube videos and perusing the internet.  Even the next day I was not sleepy, and had to force myself to nap in the afternoon.  I think by now the Halcion is cleared out of my system, and I'm relieved to have my sleep back.

Halcion: don't underestimate the power of these tiny blue pills!

On another related note: my cheeks swelled up to twice the size of my face.  I looked like a chipmunk that has stumbled on a stash of nuts in the middle of recession.  My sister laughs as she tells me I shouldn't be holding candy in my mouth anymore.  I got some sympathetic chuckles at work today for the cheeks.  On the bright side, I know what I'll look like if I ever gain 20 more pounds... very bloated.

Monday, January 10, 2011

It is no coincidence that my last post for 2010 happened to also be when I started my new job.  As they say, the more you have to write about, the less time you have to write down those thoughts.  After coming home from work, I feel so drained.  I don't know how other people do it, juggling a full-time job, attending night school, raising a family, nursing a baby, curing cancer... all at the same time.  All I feel like doing when I come home is vegetate.  It's not that I don't have stuff I want to write about, it's just difficult finding the energy & the motivation to articulate my thoughts.  And also, it probably doesn't help that I'm a bit of a freak when it comes to posting.  It's obvious I'm not going for the Pulitzer, but I have a tendency to be over-analytical about what I compose, and so I tend to over-edit, and so the whole process is that much more tedious.  But it shouldn't be tedious. This should be a therapeutic medium for me to express my opinions, no matter how biased or imperfect.  So... no more reading & re-reading, and re-re-reading, and over-editing!  Who's really going to check my sentence structure anyways?!  Write when I feel inspired, and post when I feel like it, no matter how imperfect my writing may be.

Topics dancing in my head:
- Pygmy hippos
- Blue balls
- Books!
- "Hose to the sky"
- feeding a lion rice
-toilet seats
-cystic fibrosis
-Caribbean
-E-Z Squeezy
-Ad sense?
-... and so much more.  Just have to get to it!

Monday, January 3, 2011

2011 ... Really? Really.

Just when I finally got used to dating everything 2-0-1-0, I now have to remember to date everything 2-0-1-1.  It seems like 2010 was just a blink ago...

January: brand spanking new baby nephew, fresh beginning with a new job, AVATAR!!!
February: massive snow storm, a very special Chinese New Year/V-day, sore butt from ice-skating missteps, international spies
March: more snow, Alice, aloft, I get to know
April:  flower-filled, cherry blossoms frenzy, gardens adventure, Canal walk,
May:  weekend getaways, I know more
June:  b-day celebrations, SixFlags, watermelons, kiss & makeup
July: National Zoo, Maryland blue crabs binge, Fireworks!!! unforgettable weekend getaways
August: Unbelievable b-day weekend that makes me believe in fairy tales again
September:  Fabulous Labor day weekend, horrors of human greed, an anniversary of something that has "feet" stamped all over it, fried oreos,
October: skyline drive, Lurray caverns, fall is for lovers
November: apple picking, Thomas Jefferson's home, exceptional dumplings! HARRY POTTER madness, Thanksgiving warmth, post-Thanksgiving craziness with midnight shopping on Black Friday; anticipation
December: blue blue blue waters of the Caribbeans, floating in St. Thomas, snorkeling in St. Lucia, balcony explorations, food binges, Xmas small but fulfilling, too short a staycation.

I had a beautiful 2010.  It was filled with adventures, fun, and most important, LOVE.  If there was a word to describe 2010, it would be love.  Sheer. Pure. Love.  2010 was also filled with food.  Lots of food.  I ate at so many new places and tried so many new dishes.  On the cruise alone, I ate enough food for 3 people.  I officially pronounce 2011 as the year in which I am no longer a size 0; I am officially a 2.... now if only I can strategically direct the placement of fat...

For 2011, I hope it will bring more joy and love, more experiences that I can tell to my grand-kids when I'm old and wrinkled. My resolutions... I used to not believe in this whole resolutions thing, because it seemed a bit contrived to make a list of changes only because it is the new year; why not any other time?  But I've come to not be so picky and snobby.  New year, new slate, new start.  Beautiful.

Resolutions:
1.  Write more often, at least 1 post per week.
2.  Spend less!!! no more spontaneous shopping sprees, no more impulsive buys.
3.  Keep organized: no more hoarding of junk, give away more stuff, thin out closet
4.  Use up more products
5.  Keep up with friends
6.  Drink more water
7.  Procrastinate less
8.  Pictures: take more, learn PS skillz, make prints
9.  More tree-hugging.
10. More nerd.

 Of course there are more things I could add to that list that I think would make me a better person, but I'll keep it there for now.  It's important to keep the list doable and reasonable! 

2011.  Je suis pret.